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J. Med. Microbiol. -- Vol. 51 (2002), 70-75
© 2002 Society for General Microbiology
ISSN 0022-2615

MYCOLOGY

Massive intracerebral aspergillosis responding to combination high dose liposomal amphotericin B and cytokine therapy without surgery

M. ELLIS, R. WATSON*, A. MCNABB{dagger}, M.L. LUKIC{ddagger} and M. NORK§

Departments of Medicine and {ddagger}Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, {dagger}Medicine and §Radiology, Tawam Hospital, Al Ain, UAE

Corresponding author: Professor M. Ellis (e-mail: michael.ellis{at}uaeu.ac.ae).

Received 9 May 2001; revised version accepted 10 July 2001.

Abstract

This report describes a patient with intracranial Aspergillus flavus infection in whom it was impossible to remove the fungal mass surgically. Progressive fungal infiltration of the optic nerves was reversed and the extensive intracranial fungal burden was managed successfully with combination antifungal-immunomodulatory therapy alone.




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