HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by TAYLOR-ROBINSON, D. Articles by FURR, P.M. Search for Related Content PubMed PubMed Citation Articles by TAYLOR-ROBINSON, D. Articles by FURR, P.M. Agricola Articles by TAYLOR-ROBINSON, D. Articles by FURR, P.M.

Failure of Mycoplasma pneumoniae infection to confer protection against Mycoplasma genitalium: observations from a mouse model

Imperial College School of Medicine, St. Mary's Campus, Paddington, London W2 1NY

Corresponding author: Professor D. Taylor-Robinson.

Received 4 Sept. 2000; accepted 2 Oct. 2000.

Abstract

Mycoplasma pneumoniae and M. genitalium are genomically distinct but share antigens that induce some serological cross-reactivity. Therefore, the possibility that M. pneumoniae infection of the human respiratory tract might provide immunity to M. genitalium infection of the genital tract was considered. Because of the difficulty of assessing this proposition in man, it was evaluated experimentally in a mouse model. Female BALB/c mice were susceptible to infection of the vagina with M. pneumoniae, whereas those infected previously in the oropharynx with M. pneumoniae were completely immune to infection of the vagina with this mycoplasma. However, all mice with such a respiratory tract infection were susceptible to infection of the vagina with M. genitalium. The findings suggest that an M. pneumoniae infection of the human respiratory tract is unlikely to influence infection of the genital tract by M. genitalium.

This article has been cited by other articles:

				H. F. Svenstrup, J. S. Jensen, K. Gevaert, S. Birkelund, and G. Christiansen Identification and Characterization of Immunogenic Proteins of Mycoplasma genitalium. Clin. Vaccine Immunol., August 1, 2006; 13(8): 913 - 922. [Abstract] [Full Text] [PDF]