J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SAKUTA, T.
Right arrow Articles by TORII, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SAKUTA, T.
Right arrow Articles by TORII, M.
Agricola
Right arrow Articles by SAKUTA, T.
Right arrow Articles by TORII, M.
J. Med. Microbiol. -- Vol. 50 (2001), 233-237
© 2001 Society for General Microbiology
ISSN 0022-2615

BACTERIAL PATHOGENICITY

Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1

TETSUYA SAKUTA, KENJI MATSUSHITA, NOBORU YAMAGUCHI*, TOHRU OYAMA, RIE MOTANI, TOSHIHIKO KOGA*, SHIGETAKA NAGAOKA, KAZUHIRO ABEYAMA{dagger}, IKURO MARUYAMA{dagger}, HARUHIKO TAKADA{ddagger} and MITSUO TORII

Department of Operative Dentistry and Endodontology, Kagoshima University Dental School, Kagoshima 890-8544, *Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka 812-8582, {dagger}Department of Clinical Laboratory Medicine, Kagoshima University Medical School, Kagoshima 890-8520 and {ddagger}Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai 980-8575, Japan

Corresponding author: Dr M. Torii (e-mail: toriim{at}dentb.hal.kagoshima-u.ac.jp).

Received 8 March 2000; revised version received 15 Aug. 2000; accepted 6 Sept. 2000.

Abstract

The effect of endotoxin on the regulation of vascular endothelial growth factor (VEGF) mRNA expression in human monocytic (THP-1) cells was examined. Endotoxic lipopolysaccharide (LPS) from Escherichia coli and synthetic E. coli-type lipid A (LA-15-PP) enhanced VEGF mRNA expression. LPS-induced VEGF mRNA accumulation was regulated, at least in part, at the transcriptional level. Enhancement of VEGF gene expression by LPS was shown by gel shift analysis and use of transcription factor inhibitors to be mediated via the activation of SP-1.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
G. Pages and J. Pouyssegur
Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors
Cardiovasc Res, February 15, 2005; 65(3): 564 - 573.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
H. Zheng, C. Wasylyk, A. Ayadi, J. Abecassis, J. A Schalken, H. Rogatsch, N. Wernert, S.-M. Maira, M.-C. Multon, and B. Wasylyk
The transcription factor Net regulates the angiogenic switch
Genes & Dev., September 15, 2003; 17(18): 2283 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
P.D.S. Telles, C.T. Hanks, M.A.A.M. Machado, and J.E. Nor
Lipoteichoic Acid Up-regulates VEGF Expression in Macrophages and Pulp Cells
J. Dent. Res., June 1, 2003; 82(6): 466 - 470.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Takahashi, Y. Kureishi, J. Yang, Z. Luo, K. Guo, D. Mukhopadhyay, Y. Ivashchenko, D. Branellec, and K. Walsh
Myogenic Akt Signaling Regulates Blood Vessel Recruitment during Myofiber Growth
Mol. Cell. Biol., July 1, 2002; 22(13): 4803 - 4814.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2001 Society for General Microbiology.