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J. Med. Microbiol. -- Vol. 50 (2001), 191-197
© 2001 Society for General Microbiology
ISSN 0022-2615

BACTERIAL PATHOGENICITY

Expression of type 1 fimbriae (SEF 21) of Salmonella enterica serotype Enteritidis in the early colonisation of the rat intestine

PATRICK J. NAUGHTON, GEORGE GRANT, SUSAN BARDOCZ, EMMA ALLEN-VERCOE*, MARTIN J. WOODWARD* and ARPAD PUSZTAI

Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB and *Department of Bacterial Diseases, Veterinary Laboratories Agency (Weybridge), Addlestone, Surrey KT15 3NB

Corresponding author: Dr P.J. Naughton (e-mail: Patrick.Naughton{at}agrsci.dk). Present address: Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, PO Box 50, DK-8830, Denmark.

Received 5 May 2000; revised version accepted 25 June 2000.

Abstract

The involvement of type 1 fimbriae in colonisation of the rat gastrointestinal tract in vivo was investigated with Salmonella enterica serotype Enteritidis LA5 and a mutant of LA5 denoted EAV3 unable to elaborate type 1 fimbriae (SEF 21). Rats were given a single dose of LA5 or EAV3 or a 1:1 mixture of both. LA5 was found in higher numbers in the stomach and small intestine than EAV3 at 6 h after infection with a single strain, but not after 6 days. LA5 did not out-compete EAV3 when the strains were administered together. Indeed, after 6 and 21 days, EAV3 was found in the distal small intestine and large intestine in far higher numbers than LA5. These findings suggest that SEF 21 have an important role(s) in the early stages of infection in vivo. However, SEF 21 expression may disadvantage the pathogen in the longer term as indicated by EAV3 out- competing LA5 in the gut at 21 days.




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