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Inhibition of the in-vitro growth of Mycobacterium tuberculosis by a phytosiderophore

J. RAJIV, T. DAM^*,, S. KUMAR^*, M. BOSE^*, K.K. AGGARWAL and C.R. BABU

Departments of Botany and *Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007 and School of Biotechnology, GGS Indraprastha University, Delhi 110 006, India

Corresponding author: Dr T. Dam (e-mail: tapendam@ rediffmail.com). Present address: Cell Biology Lab, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India.

Received 9 Jan. 2001; revised version received 2 March 2001; accepted 6 March 2001.

Abstract

Non-compliance by patients and poor clinical management due to the use of incorrect regimens are the main reasons for the development of drug resistance by mycobacterial strains. New strategies for the control of multi-drug-resistant mycobacterial strains have become a necessity for proper management of tuberculosis, which, according to the WHO report (1997) [1], is estimated to remain among the top 10 mortality-causing diseases of the twenty-first century. One of the strategies is the use of iron-sequestering agents like siderophores as active therapeutic agents in the treatment of tuberculosis. This report describes for the first time the inhibition of the growth of Mycobacterium tuberculosis H₃₇Ra in vitro by a phytosiderophore isolated from the root washings of Tephrosia purpurea. This finding may help in the establishment of a new drug regimen which will be more effective in the treatment of tuberculosis.

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