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J. Med. Microbiol. -- Vol. 50 (2001), 847-859
© 2001 Society for General Microbiology
ISSN 0022-2615

REVIEW ARTICLE

Cytokines, chemokines and other effector molecules involved in meningococcal disease

S.J. HACKETT*,{dagger}, A.P. J. THOMSON{dagger} and C.A. HART*

{dagger}Institute of Child Health, Royal Liverpool NHS Trust-Alder Hey, Eaton Road, Liverpool L12 2AP and *Department of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool L69 3GA

Corresponding author: Dr S. J. Hackett (e-mail: scott.hackett{at}liv.ac.uk).

Received 12 Sept. 2000; revised version received 21 Dec. 2000; accepted 23 April 2001.

Abstract

This review examines the role of cytokines and chemokines in the pathogenesis of meningococcal disease (MCD) and draws comparisons with studies of other forms of sepsis in adults and in animal models. There are many similarities but also discrepancies between these data. MCD is a well-defined clinical syndrome with identifiable onset and time of presentation. It is a reliable model in which to study cytokine and chemokine responses in bacterial sepsis. Such studies may lead to new adjunctive treatments, which can be tested to ameliorate severe MCD.




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