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J. Med. Microbiol. -- Vol. 50 (2001), 78-82
© 2001 Society for General Microbiology
ISSN 0022-2615

MYCOLOGY

Effect of fluconazole on agar invasion by Candida albicans

DIMITRIOS P. KONTOYIANNIS*, JEFFREY TARRAND{dagger}, RANDALL PRINCE*,{ddagger}, GEORGE SAMONIS*,§ and KENNETH V. R. ROLSTON*

*Section of Infectious Diseases, Department of Internal Medicine Specialties and {dagger}Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and {ddagger}College of Pharmacy, University of Houston, Houston, TX, USA

Corresponding author: Dr D.P. Kontoyiannis (e-mail: dkontoyi{at}notes.mdacc.tmc.edu). §Present address: Division of Medicine, University of Crete, PO Box 1393, Heraklion 71110, Crete, Greece.

Received 7 Dec. 1999; revised version received 2 May 2000; accepted 17 May 2000.

Abstract

Subinhibitory concentrations of azoles are known to inhibit hyphal branching of Candida albicans in liquid media. This study showed that subinhibitory concentrations of fluconazole also inhibit agar invasion by C. albicans in YPD solid medium. Agar invasion was markedly inhibited in two C. albicans strains that were resistant to fluconazole. This suggests that the degree to which fluconazole inhibits agar invasion by C. albicans hyphae could serve as a marker of susceptibility to azoles.






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