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J. Med. Microbiol. -- Vol. 49 (2000), 841-844
© 2000 Society for General Microbiology
ISSN 0022-2615

ANTIMICROBIAL AGENTS

The bactericidal activity of gemifloxacin (SB-265805)

I. MORRISSEY, S. CLARK and I. MATHIAS

GR Micro Ltd, 7–9 William Road, London NW1 3ER

Corresponding author: Dr I. Morrissey (e-mail: i.morrissey{at}grmicro.co.uk).

Received 14 Sept. 1999; revised version accepted 10 Feb. 2000.

Abstract

The bactericidal activity and mechanisms of action of the new fluoroquinolone gemifloxacin were investigated against the laboratory strains Escherichia coli KL16, Staphylococcus aureus E3T and Streptococcus pneumoniae C3LN4. Gemifloxacin was found to be highly bactericidal against these bacteria, producing a biphasic dose- response curve typical of the fluoroquinolones. This novel fluoroquinolone was more bactericidal than all other fluoroquinolones so far tested (ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, levofloxacin, clinafloxacin, trovafloxacin, DV-7751 and sitafloxacin) against S. aureus and was more bactericidal than most other fluoroquinolones against E. coli or Str. pneumoniae. These data show gemifloxacin to be an improved member of the fluoroquinolone class of antibacterial agents.




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