J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TAKAHASHI, M.
Right arrow Articles by KAMIYA, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TAKAHASHI, M.
Right arrow Articles by KAMIYA, S.
Agricola
Right arrow Articles by TAKAHASHI, M.
Right arrow Articles by KAMIYA, S.
J. Med. Microbiol. -- Vol. 49 (2000), 635-642
© 2000 Society for General Microbiology
ISSN 0022-2615

BACTERIAL PATHOGENICITY

Studies of the effect of Clostridium butyricum on Helicobacter pylori in several test models including gnotobiotic mice

MOTOMICHI TAKAHASHI*,{dagger}, HARUHIKO TAGUCHI{dagger}, HIROYUKI YAMAGUCHI{dagger}, TAKAKO OSAKI{ddagger} and SHIGERU KAMIYA{dagger}

*Miyarisan Pharmaceutical Co. Ltd, 1-10-3, Kaminakazato, Kita-ku, Tokyo, {dagger}Department of Microbiology and {ddagger}Division of Flowcytometry, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan

Corresponding author: Professor S. Kamiya (s.kamiya@ momo.so-net.ne.jp).

Received 19 April 1999; revised version received 17 Dec. 1999; accepted 22 Dec. 1999.

Abstract

The interaction between Clostridium butyricum and Helicobacter pylori was examined in vitro and in vivo. The culture supernate of C. butyricum MIYAIRI 588 inhibited the growth of H. pylori even when its pH was adjusted to 7.4. The bactericidal effect of butyric acid on H. pylori was stronger than that of lactic, acetic or hydrochloric acids. Flow cytometric analysis showed that pre-incubation of gastric epithelial (MKN45) cells with H. pylori and C. butyricum inhibited the adhesion of H. pylori to the cells. Persistent infection with H. pylori in the gastric mucosa of germ-free mice was observed for 5 weeks. Cure of persistent infection with H. pylori in the gnotobiotic mice was demonstrated following infection with C. butyricum. The probiotic agent, C. butyricum MIYAIRI 588 may have some beneficial effects on H. pylori infection.




This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
H. Sekine, H. Taguchi, H. Watanabe, S. Kawai, Y. Fujioka, H. Goto, H. Kobayashi, and S. Kamiya
Immunological analysis and pathological examination of gnotobiotic mice monoassociated with Mycoplasma pneumoniae
J. Med. Microbiol., June 1, 2009; 58(6): 697 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
F. Emura, D. Saito, T. Kakizoe, and M. J. Blaser
Infection, Cancer and Prevention: Report of the 19th International Symposium of the Foundation for Promotion of Cancer Research
Jpn. J. Clin. Oncol., November 1, 2006; 36(11): 745 - 755.
[Full Text] [PDF]

Home page
 CVIHome page
D. N. Sgouras, E. G. Panayotopoulou, B. Martinez-Gonzalez, K. Petraki, S. Michopoulos, and A. Mentis
Lactobacillus johnsonii La1 Attenuates Helicobacter pylori-Associated Gastritis and Reduces Levels of Proinflammatory Chemokines in C57BL/6 Mice
Clin. Vaccine Immunol., December 1, 2005; 12(12): 1378 - 1386.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2000 Society for General Microbiology.