J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SELA, S.
Right arrow Articles by BARZILAI, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SELA, S.
Right arrow Articles by BARZILAI, A.
Agricola
Right arrow Articles by SELA, S.
Right arrow Articles by BARZILAI, A.
J. Med. Microbiol. -- Vol. 49 (2000), 499-502
© 2000 Society for General Microbiology
ISSN 0022-2615

BACTERIAL PATHOGENICITY

Relationship between asymptomatic carriage of Streptococcus pyogenes and the ability of the strains to adhere to and be internalised by cultured epithelial cells

SHLOMO SELA, REVITAL NEEMAN, NATTAN KELLER* and ASHER BARZILAI{dagger}

Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, *Departments of Clinical Microbiology and {dagger}Paediatric Infectious Diseases Unit, Chaim Sheba Medical Centre, Tel-Hashomer Hospital, Israel

Corresponding author: Dr S. Sela (e-mail: shlomos{at}post tau.ac.il).

Received 3 Sept. 1999; revised version received 8 Nov. 1999; accepted 9 Nov. 1999.

Abstract

This study was undertaken to determine whether the ability of group A streptococci to persist in the throat following antibiotic therapy corresponded with their capacity to adhere to and be internalised by epithelial cells. The study employed a HEp-2 cell model to examine the adherence and internalisation capacities of 42 strains (13 from asymptomatic patients with bacteriological eradication failure and 29 from patients with bacterial eradication). The adherence and internalisation efficiencies of strains from symptomless carriers were significantly higher. The average adherence efficiency of the carriers’ strains was 53 (SEM 6)% versus 35 (SEM 5)% in control strains. The average internalisation efficiency of the carriers’ strains was 13.4 (SEM 4)% compared with 4.4 (SE 1.6)% in the control group. The results are in agreement with the hypothesis that, in a significant number of cases, streptococcal internalisation might contribute to eradication failure and persistent throat carriage.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
C.-C. Tsou, C. Chiang-Ni, Y.-S. Lin, W.-J. Chuang, M.-T. Lin, C.-C. Liu, and J.-J. Wu
An Iron-Binding Protein, Dpr, Decreases Hydrogen Peroxide Stress and Protects Streptococcus pyogenes against Multiple Stresses
Infect. Immun., September 1, 2008; 76(9): 4038 - 4045.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
A. Podbielski
Flexible Architecture of the Streptococcus pyogenes FCT Genome Region: Finally the Clue for Understanding Purulent Skin Diseases and Long-Term Persistence?{triangledown}
J. Bacteriol., February 15, 2007; 189(4): 1181 - 1184.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
L. Baldassarri, R. Creti, S. Recchia, M. Imperi, B. Facinelli, E. Giovanetti, M. Pataracchia, G. Alfarone, and G. Orefici
Therapeutic Failures of Antibiotics Used To Treat Macrolide-Susceptible Streptococcus pyogenes Infections May Be Due to Biofilm Formation.
J. Clin. Microbiol., August 1, 2006; 44(8): 2721 - 2727.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Wang, S. Li, P. J. Southern, and P. P. Cleary
Streptococcal modulation of cellular invasion via TGF-beta1 signaling
PNAS, February 14, 2006; 103(7): 2380 - 2385.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
D. N. Wood, M. A. Chaussee, M. S. Chaussee, and B. A. Buttaro
Persistence of Streptococcus pyogenes in Stationary-Phase Cultures
J. Bacteriol., May 15, 2005; 187(10): 3319 - 3328.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Kreikemeyer, S. Oehmcke, M. Nakata, R. Hoffrogge, and A. Podbielski
Streptococcus pyogenes Fibronectin-binding Protein F2: EXPRESSION PROFILE, BINDING CHARACTERISTICS, AND IMPACT ON EUKARYOTIC CELL INTERACTIONS
J. Biol. Chem., April 16, 2004; 279(16): 15850 - 15859.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. Spinaci, G. Magi, C. Zampaloni, L. A. Vitali, C. Paoletti, M. R. Catania, M. Prenna, L. Ferrante, S. Ripa, P. E. Varaldo, et al.
Genetic Diversity of Cell-Invasive Erythromycin-Resistant and -Susceptible Group A Streptococci Determined by Analysis of the RD2 Region of the prtF1 Gene
J. Clin. Microbiol., February 1, 2004; 42(2): 639 - 644.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
M. J. Marouni and S. Sela
Fate of Streptococcus pyogenes and epithelial cells following internalization
J. Med. Microbiol., January 1, 2004; 53(1): 1 - 7.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Pandiripally, L. Wei, C. Skerka, P. F. Zipfel, and D. Cue
Recruitment of Complement Factor H-Like Protein 1 Promotes Intracellular Invasion by Group A Streptococci
Infect. Immun., December 1, 2003; 71(12): 7119 - 7128.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. E. Bessen and A. Kalia
Genomic Localization of a T Serotype Locus to a Recombinatorial Zone Encoding Extracellular Matrix-Binding Proteins in Streptococcus pyogenes
Infect. Immun., March 1, 2002; 70(3): 1159 - 1167.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 2000 Society for General Microbiology.