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The Journal of Medical Microbiology, Vol 48, Issue 8 765-770, Copyright © 1999 by Society for General Microbiology

JOURNAL ARTICLE

Effect of passive immunotherapy on murine gut-derived sepsis caused by Pseudomonas aeruginosa

T. Matsumoto, N. Furuya, K. Tateda, S. Miyazaki, A. Ohno, Y. Ishii, Y. Hirakata and K. Yamaguchi
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.

The effect of passive immunotherapy with antisera against heat-killed Pseudomonas aeruginosa and three of its exo-enzymes (elastase, alkaline protease and exotoxin A) in gut-derived P. aeruginosa sepsis was evaluated. Mice were given a suspension of P. aeruginosa strain D4 in their drinking water, together with ampicillin (200 mg/kg) to disrupt the normal bacterial flora. Cyclophosphamide was then administered to induce translocation of P. aeruginosa that had colonised the gastrointestinal tract so that gut-derived septicaemia was produced. In this model, intraperitoneal administration of antiserum against heat-killed bacteria, 100 microl/mouse, twice a day for 3 consecutive days significantly increased the survival rate over that of mice treated with normal rabbit serum. Antiserum against elastase, alkaline protease, or a combination of these two antisera, failed to provide significant protection. In contrast, antiserum against exotoxin A significantly increased the survival rate over that of mice treated with normal rabbit serum. These results indicate that passive immunisation with antiserum against heat-killed bacteria and exotoxin A, but not with antiserum against either elastase or alkaline protease, protects mice against gut-derived sepsis caused by P. aeruginosa.


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