J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Doing, K. M.
Right arrow Articles by Volock, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doing, K. M.
Right arrow Articles by Volock, M. L.
Agricola
Right arrow Articles by Doing, K. M.
Right arrow Articles by Volock, M. L.

The Journal of Medical Microbiology, Vol 48, Issue 5 507-510, Copyright © 1999 by Society for General Microbiology

CLINICAL TRIAL

Prospective comparison of the Gen-probe PACE 2 assay and the Abbott ligase chain reaction for the direct detection of Chlamydia trachomatis in a low prevalence population

K. M. Doing, K. Curtis, J. W. Long and M. L. Volock
Department of Microbiology, Biochemistry and Molecular Biology, University of Maine, Orono 04469, USA.

In a prospective study, the Gen-Probe PACE 2 (GP) assay was compared with Abbott Laboratories' ligase chain reaction (LCR) assay for the detection of Chlamydia trachomatis. A total of 493 female patients consented to collection of two cervical samples; a first-void urine (FVU) sample was collected also from 446 of the participants. Cervical samples were tested by both GP and LCR; 16 samples (3.1%) tested positive by both methods and no discrepant results were observed. All but one of the FVU samples collected from patients with a positive cervical sample was positive for C. trachomatis by LCR. The stability of FVU samples over time in the LCR test was also evaluated and proved to be significantly longer than the 4 days stated by the manufacturer. While LCR proved to be highly sensitive in detecting chlamydial infection in FVU samples, no difference was noted between LCR and GP in the detection of cervical C. trachomatis infection in this study population.


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
E. J. WATSON, A. TEMPLETON, I. RUSSELL, J. PAAVONEN, P.-A. MARDH, A. STARY, and B. S. PEDERSON
The accuracy and efficacy of screening tests for Chlamydia trachomatis: a systematic review
J. Med. Microbiol., December 1, 2002; 51(12): 1021 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. J. Johnson, D. H. Green, D. A. Reed, and L. S. Wood
Semiautomation of Nucleic Acid-based Assays for Chlamydia trachomatis and Neisseria gonorrhoeae,
Clin. Chem., April 1, 2001; 47(4): 760 - 763.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1999 Society for General Microbiology.