The Journal of Medical Microbiology, Vol 48, Issue 3 309-315, Copyright © 1999 by Society for General Microbiology

JOURNAL ARTICLE

Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa

T. Horii, S. Ichiyama, M. Ohta and M. Kobayashi
Department of Bacteriology, Nagoya University School of Medicine, Japan.

The relationship between morphological changes and endotoxin release induced in vitro by carbapenems in a clinical isolate of Pseudomonas aeruginosa was examined. The time-course and magnitude of endotoxin release induced varied among imipenem, panipenem, meropenem and biapenem and related to the morphological changes caused by these agents which variously affected cell shape, cell-wall disintegration and cell lysis. The amount of endotoxin released by carbapenem-treated cells correlated with both the cell-wall morphology and bacterial shape immediately before lysis. Meropenem and biapenem caused markedly increased endotoxin release during cell lysis and cell-wall disintegration, whereas imipenem and panipenem caused much less release of endotoxin.

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