J Med Microbiol NEW Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giacomini, E.
Right arrow Articles by Luzzati, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giacomini, E.
Right arrow Articles by Luzzati, A. L.
Agricola
Right arrow Articles by Giacomini, E.
Right arrow Articles by Luzzati, A. L.

The Journal of Medical Microbiology, Vol 48, Issue 12 1081-1086, Copyright © 1999 by Society for General Microbiology

JOURNAL ARTICLE

Induction of a specific antibody response to Bordetella pertussis antigens in cultures of human peripheral blood mononuclear cells

E. Giacomini, F. Urbani, C. M. Ausiello and A. L. Luzzati
Department of Immunology, Istituto Superiore di Sanita, Rome, Italy.

The role of specific antibodies in protective immunity to Bordetella pertussis has not yet been clearly defined. In the present work, the induction of a specific antibody response to B. pertussis in cultures of human peripheral blood mononuclear cells (PBMC) was investigated, on the assumption that the capacity of circulating lymphocytes to mount a specific response in vitro may provide a useful parameter for the evaluation of protective immunity. When PBMC from normal adult donors were cultured with a heat-inactivated B. pertussis whole-cell suspension, cells secreting antibodies to pertussis toxin, pertactin and filamentous haemagglutinin were generated consistently. The antibody response peaked between days 7 and 11 of culture and the antibodies produced were exclusively of the IgM class.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
M. Watanabe and M. Nagai
Reciprocal Protective Immunity against Bordetella pertussis and Bordetella parapertussis in a Murine Model of Respiratory Infection
Infect. Immun., November 1, 2001; 69(11): 6981 - 6986.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
A. R. Pachner, K. Amemiya, M. Bartlett, H. Schaefer, K. Reddy, and W.-F. Zhang
Lyme Borreliosis in Rhesus Macaques: Effects of Corticosteroids on Spirochetal Load and Isotype Switching of Anti-Borrelia burgdorferi Antibody
Clin. Vaccine Immunol., March 1, 2001; 8(2): 225 - 232.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1999 Society for General Microbiology.