J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yokota, M.
Right arrow Articles by Konishi, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yokota, M.
Right arrow Articles by Konishi, H.
Agricola
Right arrow Articles by Yokota, M.
Right arrow Articles by Konishi, H.

The Journal of Medical Microbiology, Vol 46, Issue 8 675-680, Copyright © 1997 by Society for General Microbiology

JOURNAL ARTICLE

Protective activity of Borrelia duttonii-specific immunoglobulin subclasses in mice

M. Yokota, M. G. Morshed, T. Nakazawa and H. Konishi
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Japan.

To analyse the immune response of mice to Borrelia duttonii infection, BALB/c mice were inoculated intraperitoneally with B. duttonii strain 406K, and the titres of B. duttonii-specific immunoglobulins - IgM, IgG1, IgG2a, IgG2b and IgG3 - were determined by ELISA. IgM antibodies appeared first, followed by IgG2a and IgG3, and then IgG1 and IgG2b. The protective activity of individual classes and subclasses of B. duttonii-specific immunoglobulins was then determined by passive immunisation of BALB/c mice with immunoglobulin preparations purified by affinity chromatography. The mice were then challenged by intraperitoneal inoculation of B. duttonii. The study demonstrated that B. duttonii-specific IgM and IgG3 protected against the development of spirochaetaemia and death after borrelial infection, whereas B. duttonii-specific IgG1, IgG2a and IgG2b had low protective activities.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
T. J. LaRocca, L. I. Katona, D. G. Thanassi, and J. L. Benach
Bactericidal Action of a Complement-Independent Antibody against Relapsing Fever Borrelia Resides in Its Variable Region
J. Immunol., May 1, 2008; 180(9): 6222 - 6228.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. Colombo and K. R. Alugupalli
Complement Factor H-Binding Protein, a Putative Virulence Determinant of Borrelia hermsii, Is an Antigenic Target for Protective B1b Lymphocytes
J. Immunol., April 1, 2008; 180(7): 4858 - 4864.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
C. L. Lawson, B. H. Yung, A. G. Barbour, and W. R. Zuckert
Crystal Structure of Neurotropism-Associated Variable Surface Protein 1 (Vsp1) of Borrelia turicatae.
J. Bacteriol., June 1, 2006; 188(12): 4522 - 4530.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. R. Alugupalli, R. M. Gerstein, J. Chen, E. Szomolanyi-Tsuda, R. T. Woodland, and J. M. Leong
The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes
J. Immunol., April 1, 2003; 170(7): 3819 - 3827.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. G. Barbour and V. Bundoc
In Vitro and In Vivo Neutralization of the Relapsing Fever Agent Borrelia hermsii with Serotype-Specific Immunoglobulin M Antibodies
Infect. Immun., February 1, 2001; 69(2): 1009 - 1015.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1997 Society for General Microbiology.