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J Med Microbiol 46 (1997), 657-663; DOI: 10.1099/00222615-46-8-657
© 1997 Society for General Microbiology
ISSN 0022-2615
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Infection of BALB/c A mice by spiral and coccoid forms of Helicobacter pylori

X. WANG, E. STUREGÅRD, R. RUPAR, H-O. NILSSON, P. A. ALELJUNG, BIRGITTA CARLÉN*, R. WILLÉN* and T. WADSTRÖM

Department of Medical Microbiology, University of Lund, S-223 62 Lund, Sweden

*Department of Pathology, University of Lund, S-223 62 Lund, Sweden

Corresponding author: Professor T. Wadström.

Received September 24, 1996 Revision received January 10, 1997.
Accepted January 10, 1997

Helicobacter pylori exists in two different morphological forms, spiral and coccoid. This study demonstrated that both forms can infect BALB/c A mice. The animals were inoculated orally three times at 2-day intervals with 108cfu of both spiral and coccoid forms of strain CCUG 17874 (NCTC 11637), strain 25 and strain 553/93. Infection was followed over a 30-week period by histological scoring of the grade of inflammation in gastric biopsies. At each time point sera were collected for analysis in ELISA and immunoblot analysis. Both spiral and coccoid forms of all H. pylori strains gave significantly higher inflammation scores than a control group of animals 1 week after inoculation. The histological evidence persisted throughout the entire 30 weeks. The inflammation was most severe in the pylorus and duodenum. Infection with strain 553/93 displayed the most severe gastritis. The spiral form of strain CCUG 17874 gave an immune response after only 4 weeks, whereas its coccoid form as well as strains 25 and 553/93 (spiral and coccoid forms) gave a significant increase in antibody response in ELISA and immunoblot after 16 weeks. It is concluded that both spiral and coccoid forms of H. pylori can cause acute gastritis in BALB/c A mice.




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