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The Journal of Medical Microbiology, Vol 43, Issue 4 258-261, Copyright © 1995 by Society for General Microbiology

JOURNAL ARTICLE

The influence of exo-enzyme S and proteases on endogenous Pseudomonas aeruginosa bacteraemia in mice

Y. Hirakata, N. Furuya, K. Tateda, T. Matsumoto and K. Yamaguchi
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.

The role of Pseudomonas aeruginosa exo-enzymes was evaluated in a murine model of endogenous bacteraemia in which the bacteria invaded the bloodstream after oral dosing. Although an elastase mutant PAO-E64 was as virulent as its parent strain PAO1, an exo-enzyme S-deficient mutant, DG1-ExS5 and alkaline protease mutants PAKS-16, PAKS-17, PAKS-19, were less virulent than their parent strains, DG1 and PAKS-1, respectively (p < 0.01). Thus exo-enzyme S and alkaline protease, but not elastase, appear to contribute to the pathogenicity of P. aeruginosa in this model.


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