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The Journal of Medical Microbiology, Vol 42, Issue 4 299-303, Copyright © 1995 by Society for General Microbiology

JOURNAL ARTICLE

Virulence of Aspergillus fumigatus strains investigated by random amplified polymorphic DNA analysis

P. Mondon, J. Thelu, B. Lebeau, P. Ambroise-Thomas and R. Grillot
Departement de Parasitologie-Mycologie Medicale et Moleculaire (DP3M), CNRS EP J0078, Faculte de Medecine, Universite Joseph Fourier Grenoble I, La Tronche, France.

A possible relationship between the ability of Aspergillus fumigatus strains to invade tissues and genetic polymorphism was studied by random amplified polymorphic DNA (RAPD) analysis. One hundred randomly designed oligonucleotide decamers were examined with DNA of three reference strains, eight environmental isolates and 21 isolates from two distinct clinical situations: non-invasive aspergillosis (predominantly aspergilloma) and invasive aspergillosis. One primer (OPQ 6) was found to generate a reproducible amplification product that enabled distinction between the two groups according to the presence or absence of a 0.95-kb fragment that correlated with the nature of the infection (non-invasive or invasive) and immune status of the patient. The results indicated that the pathogenicity of A. fumigatus was related not only to the host's immune status but also to the virulence of the strain of A. fumigatus.


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