J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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The Journal of Medical Microbiology, Vol 40, Issue 6 389-392, Copyright © 1994 by Society for General Microbiology

JOURNAL ARTICLE

Nucleolar accumulation of Semliki Forest virus nucleocapsid C protein: influence of metabolic status, cytoskeleton and receptors

R. Jakob
Institute for Applied Cell Culture, Munich, Germany.

The nucleolar accumulation of Semliki Forest Virus (SFV) C protein was examined as a function of intact microtubules, intact microfilaments and accessible intermediate filaments. The cytoskeletal components do not seem to play a role in directing C protein to the nucleolus but nucleolar accumulation is energy-dependent and saturable. This suggests the involvement of some receptor- (or chaperon-) interaction.




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