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The Journal of Medical Microbiology, Vol 40, Issue 1 48-54, Copyright © 1994 by Society for General Microbiology

JOURNAL ARTICLE

The role of HSV-induced Fc- and C3b (i)-receptors in bacterial adherence

L. A. De Graaf-Miltenburg, K. E. Van Vliet, T. L. Ten Hagen, J. Verhoef and J. A. Van Strijp
Eijkman-Winkler Laboratory of Medical Microbiology, Utrecht University, The Netherlands.

Herpes simplex virus type-1 (HSV-1) induces Fc- and C3b(i)-receptors on infected cells. The role of these receptors in bacterial superinfection was studied by comparing the adherence of non-opsonised and opsonised bacteria to HSV-infected and non-infected HEp-2 cells. A flow cytometric adherence assay, based on the fluorescent quantitation of FITC-labelled bacteria, was developed. Opsonisation of Staphylococcus epidermidis with human serum, resulted in a marked increase in adherence to HSV-infected cells and revealed a role for C3b(i)R- and FcR-mediated adhesion. However, the enhanced adherence never exceeded the level of attachment to non-infected cells. Increased adherence of other pathogenic bacteria, including Escherichia coli, Streptococcus pneumoniae, Haemophilus influenzae and Pseudomonas aeruginosa was not observed, indicating that the HSV-receptors play a minor role in secondary infections. Bacterial adhesion factors such as the fimbriae of E. coli played a more dominant role in the adherence of bacteria to HSV-infected cells.


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M.W. RAZA, C.C. BLACKWELL, R.A. ELTON, and D.M. WEIR
Bactericidal activity of a monocytic cell line (THP-1) against common respiratory tract bacterial pathogens is depressed after infection with respiratory syncytial virus
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