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The Journal of Medical Microbiology, Vol 39, Issue 6 403-407, Copyright © 1993 by Society for General Microbiology

JOURNAL ARTICLE

Antibody response to the 89-kDa outer membrane protein of Brucella in bovine brucellosis

J. N. Limet, A. Cloeckaert, G. Bezard, J. Van Broeck and G. Dubray
Facultes Universitaires Notre Dame de la Paix, Namur, Belgium.

The antibody response of cattle to the minor 89-kDa outer-membrane protein (OMP) of brucella was measured by indirect ELISA with the purified protein and compared with the antibody response to smooth lipopolysaccharide (S-LPS). Pre-incubating sera with sonicated cell extracts of Escherichia coli prevented the binding of antibodies from uninfected animals to the 89-kDa OMP, suggesting the presence of one or more cross-reactive epitopes on this protein. In cattle infected experimentally with Brucella abortus, the antibody response to the 89-kDa OMP was later and less intense than that to S-LPS. In naturally infected cattle, 68% of animals showing an antibody response to S-LPS also showed an antibody response to the 89-kDa OMP. Results indicate that specific epitopes of the 89-kDa OMP in combination with those of other OMPs could be useful for diagnosis of brucellosis in cattle.


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