J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maciver, I.
Right arrow Articles by O'Reilly, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maciver, I.
Right arrow Articles by O'Reilly, T.
Agricola
Right arrow Articles by Maciver, I.
Right arrow Articles by O'Reilly, T.

The Journal of Medical Microbiology, Vol 35, Issue 3 139-147, Copyright © 1991 by Society for General Microbiology

JOURNAL ARTICLE

Rat model of chronic lung infections caused by non-typable Haemophilus influenzae

I. Maciver, S. H. Silverman, M. R. Brown and T. O'Reilly
Microbiology Research Group, Aston University, Birmingham.

Patients with chronic obstructive pulmonary disease (COPD) often have chronic or recurrent pulmonary infections with non-typable Haemophilus influenzae. A model of these infections exploited agar bead vehicles to protect the inoculum from rapid clearance, and a chronic lung infection of at least 42 days duration was established in rats. This infection induced increases in serum IgG titres to outer-membrane (OM) and lipo-oligosaccharide (LOS) antigens; immunoblotting demonstrated that this humoral response was directed partly against the outer-membrane proteins (OMPs). Lung lavage fluid also contained an increased titre of IgG antibodies to OM and LOS 42 days after infection. Antibodies produced during infection with one strain of H. influenzae cross-reacted with OMPs from another, non-typable H. influenzae strain. Despite their encasement in agar beads, pulmonary H. influenzae remained susceptible to amoxycillin. This model of chronic pulmonary infections due to non-typable H. influenzae appears to resemble the situation in COPD patients and may be useful for experimental therapeutic studies.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. C. Look, L. L. Stoll, S. A. Romig, A. Humlicek, B. E. Britigan, and G. M. Denning
Pyocyanin and Its Precursor Phenazine-1-Carboxylic Acid Increase IL-8 and Intercellular Adhesion Molecule-1 Expression in Human Airway Epithelial Cells by Oxidant-Dependent Mechanisms
J. Immunol., September 15, 2005; 175(6): 4017 - 4023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. L. Humlicek, L. Pang, and D. C. Look
Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1
Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L598 - L607.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. G. Frick, T. D. Joseph, L. Pang, A. M. Rabe, J. W. St. Geme III, and D. C. Look
Haemophilus influenzae Stimulates ICAM-1 Expression on Respiratory Epithelial Cells
J. Immunol., April 15, 2000; 164(8): 4185 - 4196.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1991 Society for General Microbiology.