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The Journal of Medical Microbiology, Vol 35, Issue 1 60-63, Copyright © 1991 by Society for General Microbiology

JOURNAL ARTICLE

Detection of nephritis strain-associated streptokinase by monoclonal antibodies

H. Ohkuni, Y. Todome, K. Yoshimura, T. Yamamoto, H. Suzuki, K. Yokomuro, K. H. Johnston and J. B. Zabriskie
Division of Immunology, Nippon Medical School, Kanagawa, Japan.

Monoclonal antibodies (MAbs) N-59 and RU-1 were produced by immunisation of mice with streptokinase secreted by Streptococcus group A, type 12, strain A374 isolated from a patient with post-streptococcal glomerulonephritis (PSGN) and were characterised by Western blot analysis. MAb N-59 recognised antigenic determinants shared by both nephritis strain-associated streptokinase (NSA-SKase) and streptokinase of Streptococcus group C (C-SKase); MAb RU-1 reacted only with NSA-SKase. All nephritis-associated group A streptococcal strains tested reacted with MAb N-59; 87.5% of these strains reacted with MAb RU-1. MAb N-59 reacted with SKase produced by group G streptococcal strains isolated from patients with PSGN, and MAb RU-1 recognised SKase in two out of three of these strains.


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Clin. Microbiol. Rev., July 1, 2000; 13(3): 470 - 511.
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