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The Journal of Medical Microbiology, Vol 34, Issue 3 129-135, Copyright © 1991 by Society for General Microbiology

JOURNAL ARTICLE

Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils

E. W. Odell and A. W. Segal
Department of Oral Medicine and Pathology, UMDS, Guy's Hospital, London.

The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans, a less frequent pathogen in patients with CGD, was much more susceptible.


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