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The Journal of Medical Microbiology, Vol 33, Issue 2 127-131, Copyright © 1990 by Society for General Microbiology

JOURNAL ARTICLE

Antibacterial activity of fluoroquinolones in combination with zidovudine

C. S. Lewin, R. A. Allen and S. G. Amyes
Department of Bacteriology, University of Edinburgh Medical School.

Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or Pseudomonas aeruginosa. Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.




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