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The Journal of Medical Microbiology, Vol 33, Issue 1 67-70, Copyright © 1990 by Society for General Microbiology

JOURNAL ARTICLE

Bactericidal action of PD127,391, an enhanced spectrum quinolone

C. S. Lewin and S. G. Amyes
Department of Bacteriology, University of Edinburgh Medical School.

The 4-quinolone PD127,391 displays a biphasic effect on Escherichia coli, Staphylococcus aureus and S. epidermidis in nutrient broth. It is as active as ciprofloxacin in terms of its optimum bactericidal concentration against E. coli. However, against staphylococci it is six times as active as ciprofloxacin or any other 4-quinolone previously investigated. Although protein and RNA synthesis are not required for bactericidal activity, cell division is essential.


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I. MORRISSEY, S. CLARK, and I. MATHIAS
The bactericidal activity of gemifloxacin (SB-265805)
J. Med. Microbiol., September 1, 2000; 49(9): 841 - 844.
[Abstract] [Full Text] [PDF]


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