J Med Microbiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewin, C. S.
Right arrow Articles by Smith, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewin, C. S.
Right arrow Articles by Smith, J. T.
Agricola
Right arrow Articles by Lewin, C. S.
Right arrow Articles by Smith, J. T.

The Journal of Medical Microbiology, Vol 32, Issue 3 211-214, Copyright © 1990 by Society for General Microbiology

JOURNAL ARTICLE

Conditions required for the bactericidal activity of 4-quinolones against Serratia marcescens

C. S. Lewin and J. T. Smith
Department of Bacteriology, University Medical School, Edinburgh.

The conditions required to kill Serratia marcescens with nalidixic acid, ciprofloxacin, norfloxacin or ofloxacin were determined in nutrient broth and in phosphate-buffered saline. They were found to be similar to the conditions required for these 4-quinolones to kill Escherichia coli. Bacterial RNA synthesis and bacterial cell division were essential for the bactericidal activity of nalidixic acid but all three fluoroquinolones were bactericidal against non-dividing S. marcescens. However, as with E. coli, bacterial RNA synthesis was essential for the bactericidal activity of norfloxacin though this was not required to kill S. marcescens with ciprofloxacin or ofloxacin.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1990 Society for General Microbiology.