HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by VAN RENSBURG, C. E. J. Articles by ANDERSON, R. Search for Related Content PubMed PubMed Citation Articles by VAN RENSBURG, C. E. J. Articles by ANDERSON, R. Agricola Articles by VAN RENSBURG, C. E. J. Articles by ANDERSON, R.

Interactions of the oxygen-dependent antimicrobial system of the human neutrophil with difloxacin, ciprofloxacin, pefloxacin and fleroxacin in the intraphagocytic eradication of Staphylococcus aureus

Medical Research Council Unit for the Study of Phagocyte Function, Division of Immunology, Department of Medical Microbiology, Institute for Pathology, University of Pretoria, Republic of South Africa

Received July 13, 1989 Revision received October 12, 1989.
The effect of the O²-dependent antimicrobial systems of the human neutrophil on the intraphagocytic activity of difloxacin, ciprofloxacin, pefloxacin and fleroxacin was determined by use of a radioassay with Staphylococcus aureus as the test organism. The fluoroquinolones exhibited good intraphagocytic activity with normal neutrophils. However the intracellular bioactivities of the four antimicrobial agents were substantially less in tests with neutrophils from two patients with chronic granulomatous disease. These observations suggest a synergic interaction between fluoroquinolones and the O²-dependent antimicrobial systems of phagocytes in the eradication of intracellular microbial pathogens.

This article has been cited by other articles:

				T. F. TOZUM, A. YILDIRIM, F. CAGLAYAN, A. DINCEL, and A. BOZKURT Serum and gingival crevicular fluid levels of ciprofloxacin in patients with periodontitis J Am Dent Assoc, December 1, 2004; 135(12): 1728 - 1732. [Abstract] [Full Text] [PDF]

				D. A. Cacchillo and J. D. Walters Effect of Ciprofloxacin on Killing of Actinobacillus actinomycetemcomitans by Polymorphonuclear Leukocytes Antimicrob. Agents Chemother., June 1, 2002; 46(6): 1980 - 1984. [Abstract] [Full Text] [PDF]

				M.-T. Labro Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or ""Immuno-Fairy Tales""? Clin. Microbiol. Rev., October 1, 2000; 13(4): 615 - 650. [Abstract] [Full Text] [PDF]

				S. J. Bounds, R. Nakkula, and J. D. Walters Fluoroquinolone Transport by Human Monocytes: Characterization and Comparison to Other Cells of Myeloid Lineage Antimicrob. Agents Chemother., October 1, 2000; 44(10): 2609 - 2614. [Abstract] [Full Text]

				J. D. Walters, F. Zhang, and R. J. Nakkula Mechanisms of Fluoroquinolone Transport by Human Neutrophils Antimicrob. Agents Chemother., November 1, 1999; 43(11): 2710 - 2715. [Abstract] [Full Text]

				P. J. v. den Broek, T. G. A. Koot, E. v. Strijen, and H. Mattie Intracellular activity of trovafloxacin against Staphylococcus aureus J. Antimicrob. Chemother., August 1, 1999; 44(2): 193 - 199. [Abstract] [Full Text] [PDF]

				D. Vazifeh, A. Bryskier, and M.-T. Labro Mechanism Underlying Levofloxacin Uptake by Human Polymorphonuclear Neutrophils Antimicrob. Agents Chemother., February 1, 1999; 43(2): 246 - 252. [Abstract] [Full Text]