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The Journal of Medical Microbiology, Vol 30, Issue 3 227-231, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

The bactericidal activity of DR-3355, an optically active isomer of ofloxacin

C. S. Lewin and S. G. Amyes
Department of Bacteriology, Medical School, University of Edinburgh.

The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against Escherichia coli, Staphylococcus aureus and S. epidermidis, in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration at which maximum bacterial kill was achieved. Hence it appears that DR-3355 is twice as active as ofloxacin not only in terms of its ability to inhibit bacterial multiplication but also in its ability to kill bacteria. DR-3355 was found to be active against non-dividing bacteria and did not require either active RNA or protein biosynthesis in order to kill bacteria.


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I. MORRISSEY, S. CLARK, and I. MATHIAS
The bactericidal activity of gemifloxacin (SB-265805)
J. Med. Microbiol., September 1, 2000; 49(9): 841 - 844.
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