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The Journal of Medical Microbiology, Vol 30, Issue 1 33-36, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Resistance of mice to genital infection with Neisseria gonorrhoeae

A. P. Johnson, M. Tuffrey and D. Taylor-Robinson
Division of Sexually Transmitted Diseases, M.R.C. Clinical Research Centre, Harrow, Middlesex.

Five strains of mice (C3H, CBA, BALB/c, TO and ICR) were inoculated intra-vaginally with Neisseria gonorrhoeae in an attempt to produce an animal model of gonorrhoea. Of a total of 68 mice inoculated, only three (4.4%) were culture-positive after 3 days. Histological examination of both the genital mucosa of inoculated animals, and the mucosa of genital tract organ cultures inoculated in vitro failed to show any evidence of gonococcal adherence or colonisation. Mice of these strains, therefore, appear resistant to gonococcal infection of the genital tract.


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 Infect. Immun.Home page
A. A. Soler-Garcia and A. E. Jerse
Neisseria gonorrhoeae Catalase Is Not Required for Experimental Genital Tract Infection despite the Induction of a Localized Neutrophil Response
Infect. Immun., May 1, 2007; 75(5): 2225 - 2233.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
A. E. Jerse
Experimental Gonococcal Genital Tract Infection and Opacity Protein Expression in Estradiol-Treated Mice
Infect. Immun., November 1, 1999; 67(11): 5699 - 5708.
[Abstract] [Full Text] [PDF]


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