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The Journal of Medical Microbiology, Vol 29, Issue 4 263-268, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Demonstration of a functional variant of chloramphenicol acetyltransferase in Haemophilus influenzae

M. D. Smith and M. C. Kelsey
Department of Microbiology, Whittington Hospital, London.

Seven clinical isolates of chloramphenicol-resistant Haemophilus influenzae were studied. The products of chloramphenicol inactivation by chloramphenicol acetyltransferase (CAT) were identified by high performance liquid chromatography. The sole product in H. influenzae is a single monoacetyl compound, whereas variants of CAT isolated from other chloramphenicol-resistant bacteria usually produce both monoacetyl and diacetyl chloramphenicol metabolites. The chloramphenicol resistance gene was found to reside on a 65-kb plasmid which, in five of the six cases studied, appeared to be integrated into the host cell chromosome.




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