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The Journal of Medical Microbiology, Vol 29, Issue 3 221-227, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Interactions of the 4-quinolones with other antibacterials

C. S. Lewin and J. T. Smith
Department of Pharmaceutics, School of Pharmacy, London University, Brunswick Square.

The effect of sub-inhibitory concentrations of 16 antibacterials on the bactericidal activity of the 4-quinolones nalidixic acid, ciprofloxacin and ofloxacin against Escherichia coli KL16 in nutrient broth was investigated. Sub-inhibitory concentrations of rifampicin, clindamycin, chloramphenicol, erythromycin or tetracycline antagonised the bactericidal activity of the 4-quinolones. Conversely, all seven aminoglycosides tested enhanced the bactericidal activity of the 4-quinolones whereas the cell wall antagonists, azlocillin, mezlocillin, ceftazidime and vancomycin had no effect on the bactericidal activity of the 4-quinolones.




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