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The Journal of Medical Microbiology, Vol 29, Issue 3 199-202, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Cross-reaction of immune sera from patients with rickettsial diseases

K. E. Hechemy, D. Raoult, J. Fox, Y. Han, L. B. Elliott and J. Rawlings
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.

Rickettsia rickettsii and Rickettsia conorii are the causative agents of two common and serious diseases, Rocky Mountain spotted fever and Mediterranean spotted fever, respectively. In patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. The results of this study indicate that serodiagnostic tests with antigen from one of these two organisms could be used to detect antibodies in patients with either of the two rickettsial diseases.


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