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The Journal of Medical Microbiology, Vol 29, Issue 2 131-138, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Immunogenicity of ribonucleic acid-protein fraction of Mycobacterium tuberculosis encapsulated in liposomes

P. Pancholi, V. K. Vinayak and G. K. Khuller
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Immunologically potent RNA-protein extracted from Mycobacterium tuberculosis strain H37Ra, when entrapped in phosphatidylcholine multilamellar liposomes and injected into mice, induced both cellular and humoral immune responses. Significant protection against infection with M. tuberculosis H37Rv was also induced in the immunised mice, as monitored by (i) higher survival rates, (ii) decreased viable counts of M. tuberculosis H37Rv in lungs, livers and spleens, (iii) lower lung density, and (iv) lower root specific lung weight, in comparison with a control group of unimmunized mice.


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 J Antimicrob ChemotherHome page
M. Dutt and G. K. Khuller
Chemotherapy of Mycobacterium tuberculosis infections in mice with a combination of isoniazid and rifampicin entrapped in Poly (DL-lactide-co-glycolide) microparticles
J. Antimicrob. Chemother., June 1, 2001; 47(6): 829 - 835.
[Abstract] [Full Text] [PDF]

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 Antimicrob. Agents Chemother.Home page
M. Dutt and G. K. Khuller
Therapeutic Efficacy of Poly(DL-Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice
Antimicrob. Agents Chemother., January 1, 2001; 45(1): 363 - 366.
[Abstract] [Full Text]


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