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The Journal of Medical Microbiology, Vol 29, Issue 1 33-39, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Identification of some antigenically related outer-membrane proteins of strains of Vibrio cholerae O1 and non-O1 serovars involved in intestinal adhesion and the protective role of antibodies to them

D. Sengupta, K. Datta-Roy, K. Banerjee and A. C. Ghose
Department of Immunology, National Institute of Cholera and Enteric Diseases, Calcutta, India.

Outer-membrane proteins (OMPs) of Vibrio cholerae strains of O1 and non-O1 serovars were studied. Marked similarity was found in the OMP profiles of different V. cholerae O1 strains but the OMP profile of a non-O1 strain was somewhat different. Antigenic relatedness between the OMPs of different V. cholerae strains was established by enzyme-linked immunosorbent assay (ELISA). Immunoblotting experiments demonstrated that at least two OMPs of 36 and 25-26 Kda were immunogenic and common to strains of O1 and non-O1 serovars. Antiserum raised against the outer membrane of a V. cholerae strain, and rendered specific for its OMP by absorption with lipopolysaccharide, inhibited in vitro the intestinal adhesion of the homologous and heterologous strains of V. cholerae irrespective of their biotype, serotype and serovar. Furthermore, antiserum to OMPs induced passive protection against vibrio challenge in rabbit ileal loop experiments. These results suggest that the OMPs may be useful in immunoprophylaxis against cholera.


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S. KUMAR, P. RAY, H. SINGH, and N. K. GANGULY
Immunogenicity and protective role of an IgA reactive 31-kDa antigen of Vibrio cholerae O139
J. Med. Microbiol., June 1, 2001; 50(6): 489 - 498.
[Abstract] [Full Text] [PDF]


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