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The Journal of Medical Microbiology, Vol 28, Issue 3 157-162, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Use of an antigen-capture assay for characterisation of monoclonal antibodies to mycobacterial lipoarabinomannan

S. R. Khanolkar, D. B. Young, P. J. Brennan, T. M. Buchanan and K. P. McAdam
Department of Clinical Tropical Medicine, London School of Hygiene, London.

Monoclonal antibodies directed to six separate antigen molecules of Mycobacterium leprae have been tested in an antigen-capture assay based on combined use of polyclonal ("capture") and monoclonal ("detector") antibody reagents. This approach provides a potentially versatile, sensitive and specific assay for detection and relative quantitation of M. leprae antigens. Characterisation of monoclonal antibodies to mycobacterial lipoarabinomannan (LAM-B) by the antigen-capture assay indicates that some of the antigenic determinants present on LAM-B from M. leprae may be either absent altogether or present at much lower concentrations on the corresponding LAM-B structure form M. tuberculosis.


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K.-H. Khoo, E. Douglas, P. Azadi, J. M. Inamine, G. S. Besra, P. J. Brennan, and D. Chatterjee
Truncated Structural Variants of Lipoarabinomannan in Ethambutol Drug-resistant Strains of Mycobacterium smegmatis. INHIBITION OF ARABINAN BIOSYNTHESIS BY ETHAMBUTOL
J. Biol. Chem., November 8, 1996; 271(45): 28682 - 28690.
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