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The Journal of Medical Microbiology, Vol 28, Issue 1 5-8, Copyright © 1989 by Society for General Microbiology

JOURNAL ARTICLE

Cytotoxic activity of crude extracts of Bacteroides gingivalis

P. I. Eke, B. E. Laughon and V. O. Rotimi
Department of Medical Microbiology, College of Medicine, Lagos, Nigeria.

The cytotoxic activities of culture supernates, crude cell extracts and cell-wall materials of Bacteroides gingivalis were investigated in vitro. Each component was cytotoxic to Vero cells and, to a lesser extent, Wi 38 cells. The cytotoxic agents had similar effects on the cell lines to butyric acid, propionic acid and a partially-purified trypsin-like protein extracted from a clinical isolate of B. gingivalis; the effects were eliminated by heat. Cytotoxic materials obtained from young cultures were more susceptible to heat than those from older cultures. The heart-labile substance inside and outside the bacterial cell in young cultures of B. gingivalis may contribute to its overall cytotoxic activity.


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