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The Journal of Medical Microbiology, Vol 26, Issue 4 265-268, Copyright © 1988 by Society for General Microbiology

JOURNAL ARTICLE

Cross-protection of infant mice against intestinal colonisation by Campylobacter jejuni: importance of heat-labile serotyping (Lior) antigens

A. G. Abimiku and J. M. Dolby
Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex.

An association of the heat-labile antigens detected by the Lior serotyping scheme with ability to protect infant mice against gastrointestinal colonisation with Campylobacter jejuni has been established. Overall, 39 (57%) of 68 infant mice challenged with a heterologous strain of the same Lior serotype as the vaccine strain were protected, compared with 40 (85%) of 47 infants protected against a homologous challenge. In contrast, none of the infant mice challenged with a strain carrying the same heat-stable antigens (i.e., of the same Penner serotype as the vaccine strain) were protected.


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