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The Journal of Medical Microbiology, Vol 26, Issue 2 133-141, Copyright © 1988 by Society for General Microbiology

JOURNAL ARTICLE

Alteration of pulmonary structure by Pseudomonas aeruginosa exoenzyme S

D. E. Woods, W. S. Hwang, M. S. Shahrabadi and J. U. Que
Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, Alberta, Canada.

Intratracheal administration of purified Pseudomonas aeruginosa exoenzyme S elicited extensive, grossly observable damage in the rat lung within 2 h. Light and electronmicroscopy revealed injury and necrosis of bronchial epithelium, type I pneumocytes and capillary endothelial cells after 1 h; associated haemorrhage, fibrinous exudation and released type II cell lamellar bodies in alveolar lumina after 1-12 h; progressively increasing accumulations of polymorphonuclear leucocytes in the bronchi and alveoli and in alveolar septae (interstitial pneumonia) after 1-12 h; collapse of alveolar septal connective tissue and damage to pulmonary arterioles and venules. Treatment of monolayer cultures of bronchial fibroblasts with purified exoenzyme S elicited vacuolation of the cells with apparent membrane damage as revealed by light and electronmicroscopy. In-vivo production and activity of P. aeruginosa exoenzyme S may be an important pathogenicity determinant in the necrotising lung injury characteristic of P. aeruginosa pneumonia.


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N. G. Barclay, J. C. L. Spurrell, T. F. Bruno, D. G. Storey, D. E. Woods, and C. H. Mody
Pseudomonas aeruginosa Exoenzyme S Stimulates Murine Lymphocyte Proliferation In Vitro
Infect. Immun., September 1, 1999; 67(9): 4613 - 4619.
[Abstract] [Full Text] [PDF]

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A. R. Hauser, S. Fleiszig, P. J. Kang, K. Mostov, and J. N. Engel
Defects in Type III Secretion Correlate with Internalization of Pseudomonas aeruginosa by Epithelial Cells
Infect. Immun., April 1, 1998; 66(4): 1413 - 1420.
[Abstract] [Full Text] [PDF]


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