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The Journal of Medical Microbiology, Vol 26, Issue 2 101-105, Copyright © 1988 by Society for General Microbiology

JOURNAL ARTICLE

The effect of campylobacter lipopolysaccharide on fetal development in the mouse

A. M. O'Sullivan, C. J. Dore, S. Boyle, C. R. Coid and A. P. Johnson
Division of Comparative Medicine, Clinical Research Centre, Harrow, Middlesex.

Purified lipopolysaccharide (LPS) obtained from isolates of Campylobacter fetus ss. fetus and Campylobacter jejuni impaired fetal development when administered to mice on day 13 of pregnancy. Strikingly more fetal resorption was produced by C. jejuni LPS than by similar amounts of C. fetus ss. fetus LPS. Three of the four Campylobacter strains examined produced LPS that had no effect on maternal health, but LPS from one C. jejuni strain killed all of the mice to which it was administered.


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