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The Journal of Medical Microbiology, Vol 23, Issue 3 233-238, Copyright © 1987 by Society for General Microbiology

JOURNAL ARTICLE

Interaction of Campylobacter pyloridis with human immune defence mechanisms

H. Pruul, P. C. Lee, C. S. Goodwin and P. J. McDonald

The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.


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