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The Journal of Medical Microbiology, Vol 23, Issue 3 205-210, Copyright © 1987 by Society for General Microbiology

JOURNAL ARTICLE

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

T. J. Mitchell, J. M. Ketley, D. W. Burdon, D. C. Candy and J. Stephen

Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.




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