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The Journal of Medical Microbiology, Vol 22, Issue 1 33-38, Copyright © 1986 by Society for General Microbiology

JOURNAL ARTICLE

Sporogenesis and toxin A production by Clostridium difficile

J. M. Ketley, T. J. Mitchell, S. C. Haslam, J. Stephen, D. C. Candy and D. W. Burdon

The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.


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K. Mukherjee, S. Karlsson, L. G. Burman, and T. Akerlund
Proteins released during high toxin production in Clostridium difficile
Microbiology, July 1, 2002; 148(7): 2245 - 2253.
[Abstract] [Full Text] [PDF]


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