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J Med Microbiol 21 (1986), 133-137; DOI: 10.1099/00222615-21-2-133
© 1986 Society for General Microbiology
ISSN 0022-2615
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The role of K antigens as virulence factors in Klebsiella

A. M. Simoons-Smit, A. M. J. J. Verweij-Van Vught and D. M. Maclaren

Research Group for Commercial Infections, Departments of Medical and Oral Microbiology, Schools of Medicine and Dentistry, Vrije Universiteit, 1007 MC Amsterdam, The Netherlands

Received May 10, 1985
Accepted June 25, 1985

The importance of K antigen of Klebsiella as a virulence factor was studied in nine pairs of K+ and K- strains, each pair isogenic apart from the presence of K antigen. Loss of K antigen by nine K+ strains resulted in the reduced virulence of their K- variants in a mouse-skin model. This reduced virulence of K- strains for mice may be explained in all strains by a higher degree of phagocytosis as measured by chemiluminescence response of human polymorphonuclear leukocytes (PMNL) and in most strains by enhanced killing by either human PMNL or human serum or both. Although the protective role of the K antigen in serum-induced killing and killing by PMNL was generally evident, our results also suggested that other virulence factors were sometimes involved.




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