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The Journal of Medical Microbiology, Vol 21, Issue 1 25-33, Copyright © 1986 by Society for General Microbiology

JOURNAL ARTICLE

Comparative analysis of Haemophilus influenzae type b and Escherichia coli J5 lipopolysaccharides

M. R. Hill, K. L. McKinney, M. I. Marks and R. M. Hyde

Haemophilus influenzae type b (HIB) and Escherichia coli J5 (J5) lipopolysaccharides (LPS) were examined to explore the basis of previously observed cross-protection. HIB-LPS and J5-LPS contained ketodeoxyoctonate, glucose, glucoheptose and glucosamine as common carbohydrate moieties, and laurate, myristate, beta-hydroxymyristate and palmitate as common fatty acids, although in different ratios. J5-LPS was five times more lethal than HIB-LPS for chick embryos. Weak serological cross-reactivity was observed by haemagglutination and two-dimensional immunoelectrophoresis. No significant cross-reactivity was demonstrated by enzyme-linked immunosorbent or toxicity-neutralisation assays. The cross-reactivity observed between HIB-LPS and J5-LPS was probably due to common components in the core glycolipid.


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S.E. Greisman and C.A. Johnston
Review: Evidence against the hypothesis that antibodies to the inner core of lipopolysaccharides in antisera raised by immunization with enterobacterial deep-rough mutants confer broad-spectrum protection during Gram-negative bacterial sepsis
Innate Immunity, April 1, 1997; 4(2): 123 - 153.
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