J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chandramuki, A.
Right arrow Articles by Ivanyi, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chandramuki, A.
Right arrow Articles by Ivanyi, J.
Agricola
Right arrow Articles by Chandramuki, A.
Right arrow Articles by Ivanyi, J.

The Journal of Medical Microbiology, Vol 20, Issue 2 239-247, Copyright © 1985 by Society for General Microbiology

JOURNAL ARTICLE

Detection of mycobacterial antigen and antibodies in the cerebrospinal fluid of patients with tuberculous meningitis

A. Chandramuki, P. R. Allen, M. Keen and J. Ivanyi

An immunodiagnostic test for the detection of a soluble nonprotein mycobacterial antigen by reverse passive haemagglutination with IgM murine monoclonal antibody was developed. The test was used to analyse the cerebrospinal fluid of 89 patients with tuberculous meningitis (TBM) from India and 127 control subjects from India and the UK. The antigen was demonstrable in 88% of culture-positive and 73% of culture-negative TBM patients. However, it was also detected in 21% of Indian patients with pyogenic meningitis, and in 8% of Indian and 1% of UK control subjects. Antibodies binding to a soluble mycobacterial extract were detected at low titre in 68% of all subjects with TBM and in 37% of Indian cases of pyogenic meningitis. Because patients with TBM had raised levels of the antigen and of antibodies to the antigen, the possible role of immune complexes in the pathogenesis of the disease is briefly discussed.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
R. B. Rock, M. Olin, C. A. Baker, T. W. Molitor, and P. K. Peterson
Central Nervous System Tuberculosis: Pathogenesis and Clinical Aspects
Clin. Microbiol. Rev., April 1, 2008; 21(2): 243 - 261.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1985 Society for General Microbiology.