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The Journal of Medical Microbiology, Vol 20, Issue 2 225-231, Copyright © 1985 by Society for General Microbiology

JOURNAL ARTICLE

Protection against Yersinia infection induced by non-virulence-plasmid-encoded antigens

M. Simonet, P. Berche, D. Mazigh and M. Veron

Specific immunity against Yersinia was induced by plasmid-encoded antigens not associated with virulence. Mice were immunised with viable bacteria from a virulence-plasmid-cured strain of Y. pseudotuberculosis. This antigenic stimulation generated specific protection against virulence-plasmid-harbouring strains of Y. pseudotuberculosis and Y. pestis, demonstrating that protection can be generated by organisms lacking plasmid-encoded virulence antigens.


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