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Mass Production of Human Interferon in Diploid Cells Stimulated by Poly-I:C

Rega Institute for Medical Research, University of Leuven, Belgium

The production of interferon by human diploid cells stimulated by poly-I:C can be increased by pretreatment of the cells with interferon (priming effect). Large amounts of interferon (30000 units/ml) can be obtained by combining priming with a superinduction schedule adapted from that described for rabbit kidney cultures (Tan et al. 1970; Vilcek & Ng, 1971). Human plasma protein could replace bovine serum albumin in the production medium.

Received 21 August 1972; accepted 13 November 1972.

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