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The Journal of Medical Microbiology, Vol 18, Issue 3 385-391, Copyright © 1984 by Society for General Microbiology

JOURNAL ARTICLE

Production and release of toxins A and B by Clostridium difficile

J. M. Ketley, S. C. Haslam, T. J. Mitchell, J. Stephen, D. C. Candy and D. W. Burdon

The production and release of toxins A and B by Clostridium difficile during in-vitro culture was investigated. Cell-associated toxin A was detected by immunoelectrophoresis of bacterial extracts released by ultrasonication and by fluorescent antibody labelling of whole cells. Extracellular toxin A was detected by immunoelectrophoresis and by enzyme-linked immunosorbent assay; extracellular toxin B was detected by cytotoxin assay. Both toxins A and B were produced and released during the decline phase of the bacterial growth cycle. The possible significance of these results in relation to the pathogenesis of pseudomembranous colitis is discussed.


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