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The Journal of Medical Microbiology, Vol 17, Issue 2 151-158, Copyright © 1984 by Society for General Microbiology

JOURNAL ARTICLE

The influence of drugs on the response of a cell culture preparation to bacterial toxins

L. G. Giugliano and B. S. Drasar

The influence was studied of lanthanum chloride, chlorpromazine hydrochloride, indomethacin and sodium cromoglycate on the morphological changes induced in Vero cells by the action of the cholera toxin, the thermolabile enterotoxin (LT) and the Vero cell cytotoxin (VT) of Escherichia coli, the enterotoxin of Clostridium perfringens, and the cytotoxin of Clostridium difficile. These drugs were able to inhibit the effects produced by C. difficile cytotoxin but not by the other toxins examined.




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